Marc Andreessen: “The best entrepreneurs of the future will be quite skilled at 6-8 things”

Marc is asked how being a founder changes in the age of AI, to which he responds:

“I think there are two ways to have a differentiated edge in general — go deep or go broad.”

Going deep means becoming a specialized expert in your domain.

“There are domains where that really matters,” Marc explains. “In biotech and working on AI foundation models, the deeper you are the better.”

But as AI gets more powerful, Marc would bet that “going broad” will be the winning strategy for most fields. He recommends knowing a lot about many different fields and how the world works — then use AI tools to go deep whenever you need to.

“If you talk to any of the great CEOs, you see this.” Mark explains. “The really great CEOs are great at product, sales, and marketing people, they’re great legal thinkers, and they’re great at finance and with investors and the press. It’s a multidisciplinary kind of approach.”

He continues:

“The best entrepreneurs of the future will probably be quite skilled at 6 or 8 things and then will be able to cross-pollinate and combine them.”

Full video: TBPN “Marc Andreessen on Life, Career, AI, VC, a16z and More“ (May 2025)